Projets financés

Year	Title	Duration	Lab
2021	From the investigation of the role of SRSF1 in ALS/FTD to its targeting as a therapeutic strategy	3	Prof. Frédéric Allain, ETH Zürich
2021	Molecular crosstalk between muscles and motor neurons and its role in neuromuscular circuit formation	1	Prof. Patrick Tschopp, University of Basel
2021	Molecular Diagnosis and Coping Mechanisms in Mitochondrial Myopathies	3	Prof. Alexis Jourdain, University of Lausanne
2021	IPRIMYO: Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy (Paul Pettavino Fellowship)	2	Dr. Marisa Jaconi, University of Geneva
2021	Effect of RYR1 mutations on muscle spindle function and their impact on the musculoskeletal system	1	Profs. Susan Treves and Francesco Zorzato, University Hospital Basel
2021	Therapeutic potential of human myogenic reserve cells in Duchenne Muscular Dystrophy	1	Dr. Thomas Laumonier, University of Geneva
2021	Glutamine metabolism as a potential target for Duchenne Muscular Dystrophy	1	Dr. Inés Soro-Arnàiz, ETH Zürich
2021	Targeting protein s-acylation during Tubular Aggregate Myopathy	2	Dr. Amado Carreras, University of Geneva
2021	Aggravating the phenotype of dystrophic mice for improving preclinical research and clinical translation for Duchenne muscular dystrophy	1	Dr. Olivier Dorchies, University of Geneva
2020	Characterization of autoreactive T cells in Guillain-Barré syndrome (Paul Pettavino Fellowship)	3	Dr. Daniela Latorre, ETHZ, Zürich
2020	A vascularized human muscle-on-a-chip to elucidate the contribution of endothelial-mesenchymal transition on the progression of muscular dystrophies	3	Dr. Simone Bersini, Ente Ospedaliero Cantonale, Lugano
2020	Characterization of a novel form of ALS associated with changes in the sphingolipid metabolism	3	Dr. Museer Lone, University of Zürich
2020	Pre-clinical treatment of mouse models carrying recessive Ryr1 mutations with HDAC/DNA methyltransferase inhibitors.	1	Profs. Susan Treves and Francesco Zorzato, Basel University Hospital
2020	New aspects of TGFβ signaling in muscle homeostasis and regeneration	3	Dr. Michael Bachmann University of Geneva
2020	Inhibition of sphingolipid synthesis as a treatment strategy for Duchenne muscular dystrophy	2	Prof. Johan Auwerx, EPFL, Lausanne
2019	Tamoxifen in Duchenne muscular dystrophy (TAMDMD)	2	Dr. med. Dirk Fischer, UKBB Basel
2019	DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD	2	Dr. Jochen Kinter and Dr. Christian Klingler, University of Basel
2019	Facilitating diagnosis of critical illness myopathy using muscle excitability testing	2	Prof. med. Werner J. Z'Graggen, Inselspital Bern
2019	Rapid Exploratory Imaging for High-resolution and Whole Extremity Coverage in MR Neurography	2	Dr. Olivier Scheidegger, Inselspital Bern
2019	Deciphering novel mechanisms and effectors contributing to muscle dysfunction in Myotonic Dystrophy Type I	1	Prof. Perrine Castets, University of Geneva
2018	Can HDAC/DNA methyltransferase inhibitors improve muscle function in a congenital myopathy caused by recessive RYR1 mutations?	2	Prof. Francesco Zorzato and Prof. Susan Treves, University Hospital Basel
2018	Identification of the critical regulators of protein synthesis and degradation in human muscle atrophy	2	Dr. Lionel Tintignac and Dr. Nitish Mittal, University of Basel
2018	Exploring peripheral B-cell-helper T cell phenotypes in the blood of patients with Myasthenia gravis using mass cytometry (CyTOF)	1	Dr. med. Bettina Schreiner, University Hospital Zürich
2018	Molecular signature, metabolic profile and therapeutic potential of human myogenic reserve cells	3	Dr. Thomas Laumonier, University of Geneva
2018	A multicenter cross-sectional and longitudinal study of the Swiss cohort of Merosin-negative congenital muscular dystrophy	3	Dr. med. Andrea Klein, UKBB Basel
2018	Targeting NADPH oxidase 4 in models of Duchenne muscular dystrophy (extension of project 2016)	1	Dr. Hesham Hamed, University of Geneva
2017	Characterizing the role of ER stress in C9orf72-linked ALS pathology	2	Prof. Smita Saxena, Inselspital, University of Bern
2017	Inducing mitophagy with Urolithin A to restore mitochondrial and muscle function in muscular dystrophy	2	Prof. Johan Auwerx, EPFL Lausanne
2017	Exercise‐based interventions in dysferlinopathies	2	Prof. Christoph Handschin, Biozentrum Basel
2017	Motor unit action potentials analysis in patients with myopathies with a new wireless portable and multichannel Surface EMG device (WPM-SEMG)	2	Prof. Alain Kälin, Neurocentro della Svizzera Italiana, Lugano
2017	Role and therapeutic potential of PLIN3 in neuromuscular diseases	2	Dr. Francesca Amati, University of Lausanne
2017	Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: An observational study	1	Dr. med. Thomas Riedel, Kantonsspital Graubünden, Chur
2016	Mechanism and function of genome organization in muscle development and integrity	2	Prof. Susan Gasser, Friederich Miescher Institute, Basel
2016	Role and therapeutic potential of NADPH oxidases in a mouse model of Duchenne Muscular Dystrophy	2	Dr. Hesham Hamed, University of Geneva
2016	Characterization of pathological pathways activated in muscles of patients with congenital myopathies with disturbed Ca2+ homeostasis	2	Prof. Susan Treves, Basel University Hospital
2016	Creation of a study team to conduct an SMA-1 clinical trial at the Centre for Neuromuscular Diseases at the University Children's Hospital Basel (UKBB)	1	Dr. med. Andrea Klein, Universitäts-Kinderspital beider Basel (UKBB)
2015	Novel treatment to stop progressive neuropathy and muscle weakness in multifocal motor neuropathy	3	Dr. Ruben Herrendorff, University of Basel
2015	Understanding the pathomechanisms leading to muscle alterations in Myotonic Dystrophy type I	3	Dr. Perrine Castets, University of Basel
2015	Automated volumetry and quantitative MRI to diagnose peripheral nerve lesions – translational proposal for a new clinical diagnostic imaging tool	2	Dr. Olivier Scheidegger, Inselspital Bern
2015	Novel approaches against Spinal Muscular Atrophy by targeting splicing regulators	2	Prof. Frédéric Allain, ETH Zürich
2015	Protective effects and mechanisms of action of tamoxifen in mice with severe muscular diseases	3	Dr. Olivier Dorchies, University of Geneva
2015	Role of the receptor FgfrL1 in the development of slow muscle fibers	2	Prof. Beat Trueb, University of Bern
2015	Muscle velocity recovery cycles: A new tool for early diagnosis of critical illness myopathy	1	Prof. med. Werner J. Z'Graggen, Inselpital Bern
2014	Generation of uncomitted human IPSC derived muscle stem cells for therapeutic applications	3	Dr. Florian Bentzinger, Nestlé Institute of Health Sciences, Lausanne
2014	Transposable vectors for dystrophin-expression in a murine model for muscular dystrophy	3	Prof. Nicolas Mermod, University of Lausanne
2014	Cardiac involvement in patients with Duchenne/Becker Muscular Dystrophy; an observational study	1	Dr. med. Andrea Klein, Children University Hospital Zürich
2014	Deciphering the pathogenic mechanisms of C9ORF72 ALS co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)	3	Dr. Magdalini Polymenidou, University of Zürich
2014	Development of magnetic resonance methods for functional imaging of the skeletal muscle	2	Dr. Francesco Santini, Basel University Hospital
2013	Enhancing estrogenic signalling to fight muscular dystrophies: Mechanisms of action and repurposing clinically approved drugs	2	Dr. Olivier Dorchies, University of Geneva
2013	Mechanisms and therapeutic potential of modulating PGC‐1α to alter neuromuscular junction morphology and function	2	Prof. Christoph Handschin, University of Basel
2013	Triggering human myoblast differentiation: from EGFR to myogenic transcription factors	3	Prof. Laurent Bernheim, University of Geneva
2013	Improving cellular therapies of muscle dystrophies by uncovering epigenetic and signaling pathways of muscle formation co-funded by Schweizerische Muskelgesellschaft	3	Prof. Peter Meister, University of Bern
2013	Protein engineering in an attempt to increase the mechanical, integrin dependent cytoskeleton-matrix linkage in muscle fibers	1	Prof. Bernhard Wehrle-Haller, University of Geneva
2012	Evaluation of novel treatment strategies for dysferlinopathies in mouse models	1	Prof. med. Michael Sinnreich, University Hospital Basel
2012	Cell therapy of LGMD2D by donor HLA-characterized human mesoangioblasts (hMABs) produced in GMP conditions	3	Dr. Marisa Jaconi, University of Geneva
2012	In search of small molecules targeting protein-RNA complex: a novel approach against Spinal Muscular Atrophy	3	Prof. Frédéric Allain, ETH Zürich
2012	Targeting ER stress response: a potential mechanism for neuroprotection in Amyotrophic Lateral Sclerosis co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)	1	Prof. Smita Saxena, University of Bern
2012	Restoration of autophagy as a new strategy for the treatment of congenital muscular dystrophies	3	Prof. Markus A. Rüegg, University of Basel
2011	SRP-35, a newly identified skeletal muscle protein linking excitation-contraction coupling to activation of metabolism	1	Prof. Susan Treves, University of Basel
2011	Muscle veocity recovery cycles: a new tool for characterization of muscle disease in vivo co-funded by Schweizerische Muskelgesellschaft	1.5	Prof. med. Werner J. Z'Graggen, Inselspital Bern
2011	Excessive neurotrypsin activation and agrin cleavage-a pathogenic condition leading to sarcopenia-like muscle atrophy?	1	Prof. Peter Sonderegger, University of Zürich
2010	Paramytonia and Periodic paralysis : Search for SCN4A mutations and development of an animal model	2	Prof. Anna Jawinska, University of Fribourg
2010	Pulsed Electromagnetic Fields as a Method to Improve Myoblast - Based Therapies (Mechanobiology of Muscle Development)	3	Prof. Alfredo Franco-Obregon, ETH Zürich
2010	Molecular mechanisms of mTORC1 - mediated control of muscle size and function	2	Prof. Markus A. Rüegg, University of Basel
2009	Protein engineering in an attempt to increase the mechanical, intergrin-dependant cytoskeleton-matrix linkage in muscle fibers	3	Prof. Bernhard Wehrle-Haller, University of Geneva
2009	Role of the novel receptor FGFRL1 in myoblast fusion	3	Prof. Beat Trueb, University of Bern
2009	Laminopathic myopathies : mechanisms of pathology	2	Prof. Peter Meister, Friedrich-Miescher Institute, Basel
2009	Investigation of splicing defects in Spinal Muscular Atrophy and progress toward a somatic gene therapy	3	Prof. Daniel Schümperli, University of Bern
2008	The role of the peroxisome proliferator-activated receptor ϒ coactivator 1α (PGC-1α) in ameliorating Duchenne muscular dystrophy	3	Dr. Christoph Handschin, University of Zürich
2008	Molecular basis of mTOR complex 1-dependant muscle homeostasis	2	Prof. Markus A. Rüegg, University of Basel
2008	Postnatal human myogenesis is controlled by ionic channel activity ans two sequential Ca2+- signals that activate specific signaling pathways	3	Prof. Laurent Bernheim, University of Geneva
2008	Losartan as treatment option in MDC1A mice	1	Prof. Markus A. Rüegg, University of Basel
2008	Characterization of different forms of hypokalemic periodic paralysis using refined muscle excitability measurements	1	Prof. med. Werner J. Z'Graggen, Inselspital Bern
2008	Caveolin regulation in the pathogenesis of Inclusion Body Myopathy caused by mutations in Valosin-Containing Protein (VCP)	2	Dr. Hemmo Meyer, ETH Zürich
2008	Mechanisms and role of α 7β1 integrin dynamics in muscle cells	1	Prof. Bernhard Wehrle-Haller, University of Geneva
2008	Duchenne Muscular Dystrophy : Mechanisms and Pathophysiological Implications of Ca2+ Signaling Hypersensitivity	2	Prof. Ernst Niggli, University of Bern
2008	Duchenne Muscular Dystrophy : Role of NADPH Oxidase in Calcium Signalling	2	Prof. Urs T. Ruegg, University of Geneva
2007	Molecular Mechanisms of Neuromuscular Synaps Formation : Role of Neuro-Muscular Neuregulin/ErbB signaling in the Maintenance oft he Postsynaptic Acetylcholine Receptor Density	2	Prof. Hans Rudolf Brenner, University of Basel
2007	Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy	3	Prof. Nicolas Mermod, University of Bern
2007	Molecular basis of a novel form of Nemaline Myopathy	1	Prof. Luisa Bonafè, CHUV Luasanne
2007	Is the nNOS isoform expression pattern related to the phenotype in dystrophic skeletal muscle	2	Prof. Oliver Baum, University of Bern
2007	Malfunction oft he ND1 and ND5 subunits of human complex I (repiratory NADH : quinone ocidoreductase) in MELAS syndrome	3	Prof. Julia Fritz-Steuber, University of Zürich
2007	Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy	3	Dr. Kathrin Meyer, University of Bern
2006	Dissecting the Molecular Basis of Desmin Myopathies at Atomic Detail	3	Prof. Ueli Aebi, University of Basel
2006	Molecular determinants of cell-specific aging and their impact on disease onset and progression in motoneurons and muscle	3	Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2006	A mouse model for a novel type of human myopathy	2	Prof. Beat Trueb, University of Bern
2006	Regulation of abnormal Ca2 influx observed in dystrophic mdx mice by phospholipase A2	3	Prof. Emmanuelle Roulet, University of Geneva
2006	Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein	2	Prof. Luca Borradori, University of Geneva
2005	Sarcomeric M-Band alterations characterize muscle pathogenesis	2	Prof. Irina Agarkova, ETH Zürich
2005	Role of mTOR complex 1 and mTOR complex 2 in the regulation of muscle mass	2	Prof. Markus A. Rüegg, University of Basel
2005	Functional role of JP45 in skeletal muscle excitation-contraction coupling	3	Prof. Susan Treves, University of Basel
2005	Improving myoblast survival after autologous transplantation in pigs	1	Prof. Jacques Ménétrey, University of Geneva
2005	Identification of sodium and calcium channels involved in mediating cell death in MDX mice	2	Prof. Urs T. Ruegg, University of Geneva
2005	Duchenne Muscular Dystrophy : Pathophysiological Implication of Mitochondrial Calcium Signaling and ROS Production	3	Prof. Ernst Niggli, University of Bern
2005	Mechanisms and role of α 7β1 integrin dynamics in muscle cells	3	Prof. Bernhard Wehrle-Haller, University of Geneva
2004	Development of Novel Non-Viral Vectors for a Gene Therapy of Muscular Diseases	1	Dr. Denis Bron, Myovec, Oberlinsbach
2004	Mechanism of rapsyn action in neuromuscular synapse formation	3	Prof. Christian Fuhrer, University of Zürich
2004	Investigation of the Local Activation of Glucocorticoids by 11β-Hydroxysteroid Dehydrogenase Type 1 in Skeletal Muscle and its Role in Glucocorticoid-induced Muscle Atrophy	2	Prof. Alex Odermatt, University of Bern
2004	Evaluation oft he therapeutic potential of a miniaturized gene encoding neural agrin fort he treatment of Duchenne muscular dystrophy	3	Prof. Markus A. Rüegg, University of Basel
2003	Molecular Mechanisms of Neuromuscular Synapse Formation by Agrin/MuSK: Development oft he Subsynaptic Appartus	2	Prof. Hans Rudolf Brenner, University of Basel
2003	Interactions Between Ionic Channels, Resting Potential, Calcium Signals, and Myogenic Regulatory Factors During Human Myoblast Differentiation and Fusion	3	Prof. Laurent Bernheim, University of Geneva
2003	Electrotransfer and Regulated Gene Expression fort he Gene Therapy of Duchenne Muscular Dystrophy	3	Prof. Nicolas Mermod, University of Bern
2003	Dissecting The Molecular Basis of Desmin Myopathies at Atomic Detail	3	Prof. Ueli Aebi, University of Basel
2003	Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein	2	Prof. Luca Borradori, University of Geneva
2003	Studies on the biological function oft he brain-derived neurotrophic factor precursor proBDNF	1	Prof. Joachim Weis, University of Bern
2002	Search for agents that Stabilize Utrophin mRNA in Dystrophic Muscle Cells	3	Prof. Timo Buetler, University of Lausanne
2002	Characterization and Regulation of a Physiological Pathway to Plasticity and Repair in Muscle	3	Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2002	Signaling mechanisms of muscle-specific kinase MuSK	3	Prof. Christian Fuhrer, University of Zürich
2002	Improving muscle healing using myoblast transplantation	3	Prof. Jacques Ménétrey, University of Geneva
2002	Role of a novel fibroblast growth factor receptor (FGFRL) in the control of myoblast proliferation and differentiation	3	Prof. Beat Trueb, University of Bern
2002	Functional Role of JP-45 in Skeletal Muscle Excitation-Contraction Coupling	2	Prof. Susan Treves, University of Basel

De 1987 à 2001, la fondation a financé autres 57 projets de recherche.

Projets financés

Year

Title

Duration

Lab

Projets

FSRMM