Progetti finanziati

Year

Title

Duration

Lab

2021From the investigation of the role of SRSF1 in ALS/FTD to its targeting as a therapeutic strategy3Prof. Frédéric Allain, ETH Zürich
2021Molecular crosstalk between muscles and motor neurons and its role in neuromuscular circuit formation1Prof. Patrick Tschopp, University of Basel
2021Molecular Diagnosis and Coping Mechanisms in Mitochondrial Myopathies3Prof. Alexis Jourdain, University of Lausanne
2021IPRIMYO: Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy
(Paul Pettavino Fellowship)
2Dr. Marisa Jaconi, University of Geneva
2021Effect of RYR1 mutations on muscle spindle function and their impact on the musculoskeletal system1Profs. Susan Treves and Francesco Zorzato, University Hospital Basel
2021Therapeutic potential of human myogenic reserve cells in Duchenne Muscular Dystrophy1Dr. Thomas Laumonier, University of Geneva
2021Glutamine metabolism as a potential target for Duchenne Muscular Dystrophy1Dr. Inés Soro-Arnàiz, ETH Zürich
2021Targeting protein s-acylation during Tubular Aggregate Myopathy2Dr. Amado Carreras, University of Geneva
2021Aggravating the phenotype of dystrophic mice for improving preclinical research and clinical translation for Duchenne muscular dystrophy1Dr. Olivier Dorchies, University of Geneva
2020

Characterization of autoreactive T cells in Guillain-Barré syndrome
(Paul Pettavino Fellowship)

3Dr. Daniela Latorre, ETHZ, Zürich
2020A vascularized human muscle-on-a-chip to elucidate the contribution of endothelial-mesenchymal transition on the progression of muscular dystrophies3Dr. Simone Bersini, Ente Ospedaliero Cantonale, Lugano
2020Characterization of a novel form of ALS associated with changes in the sphingolipid metabolism3

Dr. Museer Lone,
University of Zürich

2020Pre-clinical treatment of mouse models carrying recessive Ryr1 mutations with HDAC/DNA methyltransferase inhibitors.1Profs. Susan Treves and Francesco Zorzato, Basel University Hospital
2020New aspects of TGFβ signaling in muscle homeostasis and regeneration3

Dr. Michael Bachmann
University of Geneva

2020Inhibition of sphingolipid synthesis as a treatment strategy for Duchenne muscular dystrophy2Prof. Johan Auwerx, EPFL, Lausanne
2019Tamoxifen in Duchenne muscular dystrophy (TAMDMD) 2Dr. med. Dirk Fischer, UKBB Basel
2019DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD2Dr. Jochen Kinter and Dr. Christian Klingler, University of Basel
2019Facilitating diagnosis of critical illness myopathy using muscle excitability testing 2Prof. med. Werner J. Z'Graggen, Inselspital Bern
2019Rapid Exploratory Imaging for High-resolution and Whole Extremity Coverage in MR Neurography2Dr. Olivier Scheidegger, Inselspital Bern
2019Deciphering novel mechanisms and effectors contributing to muscle dysfunction in Myotonic Dystrophy Type I 1Prof. Perrine Castets, University of Geneva
2018Can HDAC/DNA methyltransferase inhibitors improve muscle function in a congenital myopathy caused by recessive RYR1 mutations?2Prof. Francesco Zorzato and Prof. Susan Treves, University Hospital Basel
2018Identification of the critical regulators of protein synthesis and degradation in human muscle atrophy2Dr. Lionel Tintignac and Dr. Nitish Mittal, University of Basel
2018Exploring peripheral B-cell-helper T cell phenotypes in the blood of patients with Myasthenia gravis using mass cytometry (CyTOF)1Dr. med. Bettina Schreiner, University Hospital Zürich
2018Molecular signature, metabolic profile and therapeutic potential of human myogenic reserve cells3Dr. Thomas Laumonier, University of Geneva
2018A multicenter cross-sectional and longitudinal study of the Swiss cohort of Merosin-negative congenital muscular dystrophy3Dr. med. Andrea Klein, UKBB Basel
2018Targeting NADPH oxidase 4 in models of Duchenne muscular dystrophy (extension of project 2016)1Dr. Hesham Hamed, University of Geneva
2017Characterizing the role of ER stress in C9orf72-linked ALS pathology2Prof. Smita Saxena, Inselspital, University of Bern
2017 Inducing mitophagy with Urolithin A to restore mitochondrial and muscle function in muscular dystrophy2Prof. Johan Auwerx, EPFL Lausanne
2017Exercise‐based interventions in dysferlinopathies2Prof. Christoph Handschin, Biozentrum Basel
2017Motor unit action potentials analysis in patients with myopathies with a new wireless portable and multichannel Surface EMG device (WPM-SEMG)2Prof. Alain Kälin, Neurocentro della Svizzera Italiana, Lugano
2017Role and therapeutic potential of PLIN3 in neuromuscular diseases2Dr. Francesca Amati, University of Lausanne
2017Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: An observational study 1Dr. med. Thomas Riedel, Kantonsspital Graubünden, Chur
2016Mechanism and function of genome organization in muscle development and integrity2Prof. Susan Gasser, Friederich Miescher Institute, Basel
2016Role and therapeutic potential of NADPH oxidases in a mouse model of Duchenne Muscular Dystrophy2Dr. Hesham Hamed, University of Geneva
2016Characterization of pathological pathways activated in muscles of patients with congenital myopathies with disturbed Ca2+ homeostasis2Prof. Susan Treves, Basel University Hospital
2016Creation of  a study team to conduct an SMA-1 clinical trial at the Centre for Neuromuscular Diseases at the University Children's Hospital Basel (UKBB)1Dr. med. Andrea Klein, Universitäts-Kinderspital beider Basel (UKBB)
2015Novel treatment to stop progressive neuropathy and muscle weakness in multifocal motor neuropathy3
 
Dr. Ruben Herrendorff, University of Basel
2015Understanding the pathomechanisms leading to muscle alterations in Myotonic Dystrophy type I3Dr. Perrine Castets, University of Basel
2015Automated volumetry and quantitative MRI to diagnose peripheral nerve lesions – translational proposal for a new clinical diagnostic imaging tool2
 
Dr. Olivier Scheidegger, Inselspital Bern
2015Novel approaches against Spinal Muscular Atrophy by targeting splicing regulators2Prof. Frédéric Allain, ETH Zürich
2015Protective effects and mechanisms of action of tamoxifen in mice with severe muscular diseases3Dr. Olivier Dorchies, University of Geneva
2015Role of the receptor FgfrL1 in the development of slow muscle fibers2Prof. Beat Trueb, University of Bern
2015Muscle velocity recovery cycles: A new tool for early diagnosis of critical illness myopathy1Prof. med. Werner J. Z'Graggen, Inselpital Bern
2014Generation of uncomitted human IPSC derived muscle stem cells for therapeutic applications3Dr. Florian Bentzinger,
Nestlé Institute of Health Sciences, Lausanne
2014Transposable vectors for dystrophin-expression in a murine model for muscular dystrophy3Prof. Nicolas Mermod,
University of Lausanne
2014Cardiac involvement in patients with Duchenne/Becker Muscular Dystrophy; an observational study1Dr. med. Andrea Klein, Children University Hospital Zürich
2014Deciphering the pathogenic mechanisms of C9ORF72 ALS
co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)
3Dr. Magdalini Polymenidou,
University of Zürich
2014Development of magnetic resonance methods for functional imaging of the skeletal muscle2Dr. Francesco Santini,
Basel University Hospital
2013Enhancing estrogenic signalling to fight muscular dystrophies: Mechanisms of action and repurposing clinically approved drugs2Dr. Olivier Dorchies, University of Geneva
2013Mechanisms and therapeutic potential of modulating PGC‐1α to alter neuromuscular junction morphology and function2Prof. Christoph Handschin, University of Basel
2013Triggering human myoblast differentiation: from EGFR to myogenic transcription factors3Prof. Laurent Bernheim, University of Geneva
2013Improving cellular therapies of muscle dystrophies by uncovering epigenetic and signaling pathways of muscle formation
co-funded by Schweizerische Muskelgesellschaft
3Prof. Peter Meister, University of Bern
2013Protein engineering in an attempt to increase the mechanical, integrin dependent cytoskeleton-matrix linkage in muscle fibers1Prof. Bernhard Wehrle-Haller, University of Geneva
2012Evaluation of novel treatment strategies for dysferlinopathies in mouse models1Prof. med. Michael Sinnreich, University Hospital Basel
2012Cell therapy of LGMD2D by donor HLA-characterized human mesoangioblasts (hMABs) produced in GMP conditions3Dr. Marisa Jaconi, University of Geneva
2012In search of small molecules targeting protein-RNA complex: a novel approach against Spinal Muscular Atrophy3Prof. Frédéric Allain, ETH Zürich
2012Targeting ER stress response: a potential mechanism for neuroprotection in Amyotrophic Lateral Sclerosis
co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)
1Prof. Smita Saxena, University of Bern
2012Restoration of autophagy as a new strategy for the treatment of congenital muscular dystrophies3Prof. Markus A. Rüegg, University of Basel
2011SRP-35, a newly identified skeletal muscle protein linking excitation-contraction coupling to activation of metabolism1Prof. Susan Treves, University of Basel
2011

Muscle veocity recovery cycles: a new tool for characterization of muscle disease in vivo
co-funded by Schweizerische Muskelgesellschaft

1.5Prof. med. Werner J. Z'Graggen, Inselspital Bern
2011Excessive neurotrypsin activation and agrin cleavage-a pathogenic condition leading to sarcopenia-like muscle atrophy?1Prof. Peter Sonderegger, University of Zürich
2010Paramytonia and Periodic paralysis : Search for SCN4A mutations and development of an animal model2Prof. Anna Jawinska, University of Fribourg
2010Pulsed Electromagnetic Fields as a Method to Improve Myoblast - Based Therapies (Mechanobiology of Muscle Development)3Prof. Alfredo Franco-Obregon, ETH Zürich
2010Molecular mechanisms of mTORC1 - mediated control of muscle size and function2Prof. Markus A. Rüegg, University of Basel
2009Protein engineering in an attempt to increase the mechanical, intergrin-dependant cytoskeleton-matrix linkage in muscle fibers3Prof. Bernhard Wehrle-Haller, University of Geneva
2009Role of the novel receptor FGFRL1 in myoblast fusion3Prof. Beat Trueb, University of Bern
2009Laminopathic myopathies : mechanisms of pathology2Prof. Peter Meister, Friedrich-Miescher Institute, Basel
2009Investigation of splicing defects in Spinal Muscular Atrophy and progress toward a somatic gene therapy3Prof. Daniel Schümperli, University of Bern
2008The role of the peroxisome proliferator-activated receptor ϒ coactivator 1α (PGC-1α) in ameliorating Duchenne muscular dystrophy3Dr. Christoph Handschin, University of Zürich
2008Molecular basis of mTOR complex 1-dependant muscle homeostasis2Prof. Markus A. Rüegg, University of Basel
2008
Postnatal human myogenesis is controlled by ionic channel activity ans two sequential Ca2+- signals that activate specific signaling pathways
3
 
Prof. Laurent Bernheim, University of Geneva
2008Losartan as treatment option in MDC1A mice1Prof. Markus A. Rüegg, University of Basel
2008Characterization of different forms of hypokalemic periodic paralysis using refined muscle excitability measurements1Prof. med. Werner J. Z'Graggen, Inselspital Bern
2008Caveolin regulation in the pathogenesis of Inclusion Body Myopathy caused by mutations in Valosin-Containing Protein (VCP)2Dr. Hemmo Meyer, ETH Zürich
2008Mechanisms and role of α 7β1 integrin dynamics in muscle cells1Prof. Bernhard Wehrle-Haller, University of Geneva
2008Duchenne Muscular Dystrophy : Mechanisms and Pathophysiological Implications of Ca2+ Signaling Hypersensitivity2Prof. Ernst Niggli, University of Bern
2008Duchenne Muscular Dystrophy : Role of NADPH Oxidase in Calcium Signalling2Prof. Urs T. Ruegg, University of Geneva
2007Molecular Mechanisms of Neuromuscular Synaps Formation : Role of Neuro-Muscular Neuregulin/ErbB signaling in the Maintenance oft he Postsynaptic Acetylcholine Receptor Density2Prof. Hans Rudolf Brenner, University of Basel
2007Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy3Prof. Nicolas Mermod, University of Bern
2007Molecular basis of a novel form of Nemaline Myopathy1Prof. Luisa Bonafè, CHUV Luasanne
2007Is the nNOS isoform expression pattern related to the phenotype in dystrophic skeletal muscle2Prof. Oliver Baum, University of Bern
2007Malfunction oft he ND1 and ND5 subunits of human complex I (repiratory NADH : quinone ocidoreductase) in MELAS syndrome3Prof. Julia Fritz-Steuber, University of Zürich
2007Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy3Dr. Kathrin Meyer, University of Bern
2006Dissecting the Molecular Basis of Desmin Myopathies at Atomic Detail3Prof. Ueli Aebi, University of Basel
2006Molecular determinants of cell-specific aging and their impact on disease onset and progression in motoneurons and muscle3Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2006A mouse model for a novel type of human myopathy2Prof. Beat Trueb, University of Bern
2006Regulation of abnormal Ca2 influx observed in dystrophic mdx mice by phospholipase A23Prof. Emmanuelle Roulet, University of Geneva
2006Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein2Prof. Luca Borradori, University of Geneva
2005Sarcomeric M-Band alterations characterize muscle pathogenesis2Prof. Irina Agarkova, ETH Zürich
2005Role of mTOR complex 1 and mTOR complex 2 in the regulation of muscle mass2Prof. Markus A. Rüegg, University of Basel
2005Functional role of JP45 in skeletal muscle excitation-contraction coupling3Prof. Susan Treves, University of Basel
2005Improving myoblast survival after autologous transplantation in pigs1Prof. Jacques Ménétrey, University of Geneva
2005Identification of sodium and calcium channels involved in mediating cell death in MDX mice2Prof. Urs T. Ruegg, University of Geneva
2005Duchenne Muscular Dystrophy : Pathophysiological Implication of Mitochondrial Calcium Signaling and ROS Production3Prof. Ernst Niggli, University of Bern
2005Mechanisms and role of α 7β1 integrin dynamics in muscle cells3Prof. Bernhard Wehrle-Haller, University of Geneva
2004Development of Novel Non-Viral Vectors for a Gene Therapy of Muscular Diseases1Dr. Denis Bron, Myovec, Oberlinsbach
2004Mechanism of rapsyn action in neuromuscular synapse formation3Prof. Christian Fuhrer, University of Zürich
2004Investigation of the Local Activation of Glucocorticoids by 11β-Hydroxysteroid Dehydrogenase Type 1 in Skeletal Muscle and its Role in Glucocorticoid-induced Muscle Atrophy2Prof. Alex Odermatt, University of Bern
2004Evaluation oft he therapeutic potential of a miniaturized gene encoding neural agrin fort he treatment of Duchenne muscular dystrophy3Prof. Markus A. Rüegg, University of Basel
2003Molecular Mechanisms of Neuromuscular Synapse Formation by Agrin/MuSK: Development oft he Subsynaptic Appartus2Prof. Hans Rudolf Brenner, University of Basel
2003Interactions Between Ionic Channels, Resting Potential, Calcium Signals, and Myogenic Regulatory Factors During Human Myoblast Differentiation and Fusion3Prof. Laurent Bernheim, University of Geneva
2003Electrotransfer and Regulated Gene Expression fort he Gene Therapy of Duchenne Muscular Dystrophy3Prof. Nicolas Mermod, University of Bern
2003Dissecting The Molecular Basis of Desmin Myopathies at Atomic Detail3Prof. Ueli Aebi, University of Basel
2003Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein2Prof. Luca Borradori, University of Geneva
2003Studies on the biological function oft he brain-derived neurotrophic factor precursor proBDNF1Prof. Joachim Weis, University of Bern
2002Search for agents that Stabilize Utrophin mRNA in Dystrophic Muscle Cells3Prof. Timo Buetler, University of Lausanne
2002Characterization and Regulation of a Physiological Pathway to Plasticity and Repair in Muscle3Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2002Signaling mechanisms of muscle-specific kinase MuSK3Prof. Christian Fuhrer, University of Zürich
2002Improving muscle healing using myoblast transplantation3Prof. Jacques Ménétrey, University of Geneva
2002Role of a novel fibroblast growth factor receptor (FGFRL) in the control of myoblast proliferation and differentiation3Prof. Beat Trueb, University of Bern
2002Functional Role of JP-45 in Skeletal Muscle Excitation-Contraction Coupling2Prof. Susan Treves, University of Basel

 

Dal 1987 al 2001, la Fondazione ha finanziato altri 57 progetti di ricerca.