Finanzierte Projekte

Year

Title

Duration

Lab

2016Mechanism and function of genome organization in muscle development and integrity2Prof. Susan Gasser, Friederich Miescher Institute, Basel
2016Role and therapeutic potential of NADPH oxidases in a mouse model of Duchenne Muscular Dystrophy2Dr. Hesham Hamed, University of Geneva
2016Characterization of pathological pathways activated in muscles of patients with congenital myopathies with disturbed Ca2+ homeostasis2Prof. Susan Treves, Basel University Hospital
2016Creation of  a study team to conduct an SMA-1 clinical trial at the Centre for Neuromuscular Diseases at the University Children's Hospital Basel (UKBB)1Dr. med. Andrea Klein, Universitäts-Kinderspital beider Basel (UKBB)
2015Novel treatment to stop progressive neuropathy and muscle weakness in multifocal motor neuropathy3

Dr. Ruben Herrendorff, University of Basel
2015Understanding the pathomechanisms leading to muscle alterations in Myotonic Dystrophy type I3Dr. Perrine Castets, University of Basel
2015Automated volumetry and quantitative MRI to diagnose peripheral nerve lesions – translational proposal for a new clinical diagnostic imaging tool2

Dr. Olivier Scheidegger, Inselspital Bern
2015Novel approaches against Spinal Muscular Atrophy by targeting splicing regulators2Prof. Frédéric Allain, ETH Zürich
2015Protective effects and mechanisms of action of tamoxifen in mice with severe muscular diseases3Dr. Olivier Dorchies, University of Geneva
2015Role of the receptor FgfrL1 in the development of slow muscle fibers2Prof. Beat Trueb, University of Bern
2015Muscle velocity recovery cycles: A new tool for early diagnosis of critical illness myopathy1Prof. med. Werner J. Z'Graggen, Inselpital Bern
2014Generation of uncomitted human IPSC derived muscle stem cells for therapeutic applications3Dr. Florian Bentzinger,
Nestlé Institute of Health Sciences, Lausanne
2014Transposable vectors for dystrophin-expression in a murine model for muscular dystrophy3Prof. Nicolas Mermod,
University of Lausanne
2014Cardiac involvement in patients with Duchenne/Becker Muscular Dystrophy; an observational study1Dr. Andrea Klein, Children University Hospital Zürich
2014Deciphering the pathogenic mechanisms of C9ORF72 ALS
co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)
3Dr. Magdalini Polymenidou,
University of Zürich
2014Development of magnetic resonance methods for functional imaging of the skeletal muscle2Dr. Francesco Santini,
Basel University Hospital
2013Enhancing estrogenic signalling to fight muscular dystrophies: Mechanisms of action and repurposing clinically approved drugs2Dr. Oliver Dorchies, University of Geneva
2013Mechanisms and therapeutic potential of modulating PGC‐1α to alter neuromuscular junction morphology and function2Prof. Christoph Handschin, University of Basel
2013Triggering human myoblast differentiation: from EGFR to myogenic transcription factors3Prof. Laurent Bernheim, University of Geneva
2013Improving cellular therapies of muscle dystrophies by uncovering epigenetic and signaling pathways of muscle formation
co-funded by Schweizerische Muskelgesellschaft
3Prof. Peter Meister, University of Bern
2013Protein engineering in an attempt to increase the mechanical, integrin dependent cytoskeleton-matrix linkage in muscle fibers1Prof. Bernhard Wehrle-Haller, University of Geneva
2012Evaluation of novel treatment strategies for dysferlinopathies in mouse models1Prof. Michael Sinnreich, University Hospital Basel
2012Cell therapy of LGMD2D by donor HLA-characterized human mesoangioblasts (hMABs) produced in GMP conditions3Dr. Marisa Jaconi, University of Geneva
2012In search of small molecules targeting protein-RNA complex: a novel approach against Spinal Muscular Atrophy3Prof. Frédéric Allain, ETH Zürich
2012Targeting ER stress response: a potential mechanism for neuroprotection in Amyotrophic Lateral Sclerosis
co-funded by ASLASI (Associazione Sclerosi Laterale Amiotrofica Svizzera Italiana)
1Prof. Smita Saxena, University of Bern
2012Restoration of autophagy as a new strategy for the treatment of congenital muscular dystrophies3Prof. Markus A. Rüegg, University of Basel
2011SRP-35, a newly identified skeletal muscle protein linking excitation-contraction coupling to activation of metabolism1Prof. Susan Treves, University of Basel
2011

Muscle veocity recovery cycles: a new tool for characterization of muscle disease in vivo
co-funded by Schweizerische Muskelgesellschaft

1.5Prof. med. Werner J. Z'Graggen, Inselpital Bern
2011Excessive neurotrypsin activation and agrin cleavage-a pathogenic condition leading to sarcopenia-like muscle atrophy?1Prof. Peter Sonderegger, University of Zürich
2010Paramytonia and Periodic paralysis : Search for SCN4A mutations and development of an animal model2Prof. Anna Jawinska, University of Fribourg
2010Pulsed Electromagnetic Fields as a Method to Improve Myoblast - Based Therapies (Mechanobiology of Muscle Development)3Prof. Alfredo Franco-Obregon, ETH Zürich
2010Molecular mechanisms of mTORC1 - mediated control of muscle size and function2Prof. Markus A. Rüegg, University of Basel
2009Protein engineering in an attempt to increase the mechanical, intergrin-dependant cytoskeleton-matrix linkage in muscle fibers3Prof. Bernhard Wehrle-Haller, University of Geneva
2009Role of the novel receptor FGFRL1 in myoblast fusion3Prof. Beat Trueb, University of Bern
2009Laminopathic myopathies : mechanisms of pathology2Prof. Peter Meister, Friedrich-Miescher Institute, Basel
2009Investigation of splicing defects in Spinal Muscular Atrophy and progress toward a somatic gene therapy3Prof. Daniel Schümperli, University of Bern
2008The role of the peroxisome proliferator-activated receptor ϒ coactivator 1α (PGC-1α) in ameliorating Duchenne muscular dystrophy3Christoph Handschin, University of Zürich
2008Molecular basis of mTOR complex 1-dependant muscle homeostasis2Prof. Markus A. Rüegg, University of Basel
2008
Postnatal human myogenesis is controlled by ionic channel activity ans two sequential Ca2+- signals that activate specific signaling pathways
3

Prof. Laurent Bernheim, University of Geneva
2008Losartan as treatment option in MDC1A mice1Prof. Markus A. Rüegg, University of Basel
2008Characterization of different forms of hypokalemic periodic paralysis using refined muscle excitability measurements1Prof. Werner J. Z'Graggen, Inselspital Bern
2008Caveolin regulation in the pathogenesis of Inclusion Body Myopathy caused by mutations in Valosin-Containing Protein (VCP)2Dr. Hemmo Meyer, ETH Zürich
2008Mechanisms and role of α 7β1 integrin dynamics in muscle cells1Prof. Bernhard Wehrle-Haller, University of Geneva
2008Duchenne Muscular Dystrophy : Mechanisms and Pathophysiological Implications of Ca2+ Signaling Hypersensitivity2Prof. Ernst Niggli, University of Bern
2008Duchenne Muscular Dystrophy : Role of NADPH Oxidase in Calcium Signalling2Prof. Urs T. Ruegg, University of Geneva
2007Molecular Mechanisms of Neuromuscular Synaps Formation : Role of Neuro-Muscular Neuregulin/ErbB signaling in the Maintenance oft he Postsynaptic Acetylcholine Receptor Density2Prof. Hans Rudolf Brenner, University of Basel
2007Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy3Prof. Nicolas P. Mermod, University of Bern
2007Molecular basis of a novel form of Nemaline Myopathy1Prof. Luisa Bonafè, CHUV Luasanne
2007Is the nNOS isoform expression pattern related to the phenotype in dystrophic skeletal muscle2Prof. Oliver Baum, University of Bern
2007Malfunction oft he ND1 and ND5 subunits of human complex I (repiratory NADH : quinone ocidoreductase) in MELAS syndrome3Prof. Julia Fritz-Steuber, University of Zürich
2007Investigation of a specific role of SMN and its potential in a gene therapy for Spinal Muscular Atrophy3Dr. Kathrin Meyer, University of Bern
2006Dissecting the Molecular Basis of Desmin Myopathies at Atomic Detail3Prof. Ueli Aebi, University of Basel
2006Molecular determinants of cell-specific aging and their impact on disease onset and progression in motoneurons and muscle3Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2006A mouse model for a novel type of human myopathy2Prof. Beat Trueb, University of Bern
2006Regulation of abnormal Ca2 influx observed in dystrophic mdx mice by phospholipase A23Prof. Emmanuelle Roulet, University of Geneva
2006Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein2Prof. Luca Borradori, University of Geneva
2005Sarcomeric M-Band alterations characterize muscle pathogenesis2Prof. Irina Agarkova, ETH Zürich
2005Role of mTOR complex 1 and mTOR complex 2 in the regulation of muscle mass2Prof. Markus A. Rüegg, University of Basel
2005Functional role of JP45 in skeletal muscle excitation-contraction coupling3Prof. Susan Treves, University of Basel
2005Improving myoblast survival after autologous transplantation in pigs1Prof. Jacques Ménétrey, University of Geneva
2005Identification of sodium and calcium channels involved in mediating cell death in MDX mice2Prof. Urs T. Ruegg, University of Geneva
2005Duchenne Muscular Dystrophy : Pathophysiological Implication of Mitochondrial Calcium Signaling and ROS Production3Prof. Ernst Niggli, University of Bern
2005Mechanisms and role of α 7β1 integrin dynamics in muscle cells3Prof. Bernhard Wehrle-Haller, University of Geneva
2004Development of Novel Non-Viral Vectors for a Gene Therapy of Muscular Diseases1Dr. Denis Bron, Myovec, Oberlinsbach
2004Mechanism of rapsyn action in neuromuscular synapse formation3Prof. Christian Fuhrer, University of Zürich
2004Investigation of the Local Activation of Glucocorticoids by 11β-Hydroxysteroid Dehydrogenase Type 1 in Skeletal Muscle and its Role in Glucocorticoid-induced Muscle Atrophy2Prof. Alex Odermatt, University of Bern
2004Evaluation oft he therapeutic potential of a miniaturized gene encoding neural agrin fort he treatment of Duchenne muscular dystrophy3Prof. Markus A. Rüegg, University of Basel
2003Molecular Mechanisms of Neuromuscular Synapse Formation by Agrin/MuSK: Development oft he Subsynaptic Appartus2Prof. Hans Rudolf Brenner, University of Basel
2003Interactions Between Ionic Channels, Resting Potential, Calcium Signals, and Myogenic Regulatory Factors During Human Myoblast Differentiation and Fusion3Prof. Laurent Bernheim, University of Geneva
2003Electrotransfer and Regulated Gene Expression fort he Gene Therapy of Duchenne Muscular Dystrophy3Prof. Nicolas P. Mermod, University of Bern
2003Dissecting The Molecular Basis of Desmin Myopathies at Atomic Detail3Prof. Ueli Aebi, University of Basel
2003Analysis oft he Interaction of Desmoplakin and Plectin with Desmin and Characterization oft he Binding Partners of Synemin, a Novel Intermediate Filament Protein2Prof. Luca Borradori, University of Geneva
2003Studies on the biological function oft he brain-derived neurotrophic factor precursor proBDNF1Prof. Joachim Weis, University of Bern
2002Search for agents that Stabilize Utrophin mRNA in Dystrophic Muscle Cells3Prof. Timo Buetler, University of Lausanne
2002Characterization and Regulation of a Physiological Pathway to Plasticity and Repair in Muscle3Prof. Pico Caroni, Friedrich-Miescher Institute, Basel
2002Signaling mechanisms of muscle-specific kinase MuSK3Prof. Christian Fuhrer, University of Zürich
2002Improving muscle healing using myoblast transplantation3Prof. Jacques Ménétrey, University of Geneva
2002Role of a novel fibroblast growth factor receptor (FGFRL) in the control of myoblast proliferation and differentiation3Prof. Beat Trueb, University of Bern
2002Functional Role of JP-45 in Skeletal Muscle Excitation-Contraction Coupling2Prof. Susan Treves, University of Basel

 

Von 1987 bis 2001 hat die Stiftung 57 weitere Forschungsprojekte finanziert.