Swiss scientists network

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Lab Prof. Hugues Abriel

Institute of Biochemistry and Molecular Medicine, University of Bern

Institute infrastructure: Cell culture and microscopy techniques, electrophysiology (conventional and automated patch-clamp), protein interaction techniques, animal facility

TeamPersonal expertise
Prof. Hugues Abrielchannelopathies, ion channels and protein-protein interactions 
Maria Essers
lab manager, technician
Animal surgery, biochemistry, immunostaining, protein-protein proximity assay, cardiomyocytes isolation, Langendorff
Sabrina Guichard
Cardiomyocytes isolation, genotyping, molecular cloning, generation transgenic animal

Dr. Jean-Sébastien Rougier
senior scientist
Patch-clamp, molecular cloning, protein-protein proximity assay, immunostaining

Dr. Lijo Ozhathil
Patch-clamp, atrial cardiomyocytes isolation, RT-qPCR
Dr. Urs Thomet

Patch-clamp, molecular cloning, RT-qPCR

Beatrice Bianchi
PhD student
Biochemistry (Western blot, co-immunoprecipitation, biotinylation, cell membrane preparation)

Morgan Chevalier
PhD student
Patch-Clamp, molecular cloning, ventricular cardiomyocytes isolation, protein-protein proximity assay
Sarah Helena Vermij 
PhD student
Biochemistry (Western blot, co-immunoprecipitation, biotinylation), immunostaining, protein-protein proximity assay
Zizun Wang 
PhD student
Patch clamp, biochemistry (Western blot, biotinylation)



Lab Prof. Frédéric Allain

Institute of molecular and biological physics, ETH Zürich

Institute infrastructure: Determination of structures at atomic resolution of Protein-RNA complexes using Nuclear Magnetic Resonance spectroscopy (NMR)

TeamPersonal expertise
Prof. Frédéric Allain
Dr. Antoine Cléry
senior scientist
Irene Beusch
PhD student
muscle EMBL
Ahmed Moursy
PhD student



Lab Prof. Francesca Amati

Aging and Muscle Metabolism lab, Department of Physiology & Institute of Sport Sciences, University of Lausanne

Lab infrastructure: Human physiology and metabolism research lab including exercise testing, exercise intervention, stable isotope tracers, glucose clamps, indirect calorimetry, body composition.
Zebrafish facility, breeding, exercise testing and training.
Primary muscle cell cultures, respirometry, mitochondria isolation, wet lab, microsopy


TeamPersonal expertise
Prof. Francesca AmatiClinical and translational research in muscle metabolism and aging, including muscle wasting, sarcopenia, insulin resistance and the development of other chronic diseases related to muscle metabolism.  
Dr. Yoan Arribat
Zebrafish, neuromuscular models
Dr. Sylviane Lagarrigue
Mitochondrial metabolism, primary cell cultures

Sonia Conde Alonso
PhD student
Exercise physiology

Dogan Grepper
PhD student




Lab Prof. Laurent Bernheim

University of Geneva, Department of Neurosciences

Institute infrastructure: Calcium bioimaging, Electrophysiology, human primary cell culture, small animal bioimaging

TeamPersonal expertise
Laurent Bernheim
Myogenesis, Muscle regeneration, Muscular dystrophies, Electrophysiology
Maud Frieden
Electrophysiology, Bioimaging, STIM1, SOCE
Stephane Koenig
scientific collaborator
Molecular biology, myogenesis and muscle regeneration, virus, Signal transduction
Julie Perroud
PhD student
Biochemistry, EGFR, Kir2.1
Sophie Saüc
PhD student
Myoblast differentiation, Signal transduction, Ca++ imaging
Agnieszka Dyrda
PhD student




Lab Prof. Christoph Handschin

Biozentrum, University of Basel

Institute infrastructure: Treadmill (open and closed), voluntary wheel running, grip strength, CLAMS (comprehensive laboratory animal monitoring system), qNMR (body composition)

TeamPersonal expertise
Prof. Christoph HandschinSkeletal muscle cell plasticity in health and disease incl. exercise and muscle wasting pathologies
Dr. Regula Furrer
satellite cells isolation
Jonathan Gill
PhD student
Neuromuscular junction plasticity
Martin Weihrauch
PhD student
NMJ isolation, transcriptome, imaging



Lab Prof. Didier Hannouche & Dr. Thomas Laumonier

Department of Orthopaedic Surgery,Faculty of Medicine  & University Hospital, Geneva, Switzerland

Institute infrastructure: Hypoxic chamber, Whole Animal System for muscle physiology testing in mice, bioluminescence imaging.

TeamPersonal expertise
Didier Hannouche
Professor, MD-PhD Co-responsible of the lab
Orthopaedic surgery, cell therapy
Dr. Thomas Laumonier
Senior scientist, Co-responsible of the lab
Isolation of human myogenic stem cells, cell therapy, immunology, flow cytometry, muscle regeneration, gene therapy, bioluminescence imaging
Nicolette Brouwers
Isolation of primary human cells, flow cytometry, T cell proliferation assay
Salvatore Santangelo
Master student
Cell culture, flow cytometry, calcium imaging, western blot
Karim Oudina
Animal surgery, PCR, western blot



Lab Prof. Marisa Jaconi

University of Geneva, Department of Pathology and Immunology

Institute infrastructure: Cell culture and microscopy techniques; GMP lab; muscle physiology; animal facility and analysis of muscle function

TeamPersonal expertise
Marisa Jaconi
Musle human pluripotent stem cells (ESC and iPSC), cardiogenesis, and myogenesis,  muscle differentiation, tissue engineering, cell therapy strategies
Dr. Flavio Ronzoni
Mesoangioblast isolation, biology and functional analysis, cell therapy administration, GMP isolation and qualifications
Stefano Jaconi
Pluripotent stem cells, hESC culture



Lab Prof. Peter Meister

Institute of Cell Bioogy, University of Bern

Institute infrastructure: Confocal Microscopy, Spinning Disk microscopy for live and Calcium imaging

TeamPersonal expertise
SNF Prof. 
Peter Meister
C. elegans, muscle differentiation, epigenetics, nuclear organization, microscopy
Francesca Coraggio
PhD student
Cell plasticity, muscle cell induction, pluripotency, genetic screens



Lab Prof. Nicolas Mermod

University of Lausanne, Biotechnology

Institute infrastructureMuscle in situ electroporation, integrating and non-integrating non-viral DNA expression vectors, Next-generation DNA sequencing and genomics

TeamPersonal expertise
Nicolas Mermod
Gene  expression  and regulation, genomics, epigenetic regulatory elements, non-viral vectors
Pavitra Iyer
PhD student
gene transfer in cultured muscle progenitor cells and transplantation



Lab Prof. Markus A. Rüegg

University of Basel, Biozentrum

Institute infrastructure: Muscle electroporation; muscle force measurement; microscopy;cell culture; tread mill; voluntary wheel running; brain physiology.

TeamPersonal expertise
Markus A. Rüegg
Synapse formation in skeletal muscle and in the brain; transgenic animal models; neuromuscular muscular diseases.
Dr. Shuo Lin
Development of neuromuscular junctions; muscle growth and muscular dystrophies.
Dr. Perrine Castets
Cell Biology, Biochemistry, Molecular Biology, Muscle Development & Homeostasis
Dr. Daniel J. Ham
ageing, sarcopenia
Dr. Giulia Milan
senescence, mTOR-Akt signalling
Dr. Judith Reinhard
Nathalie Rion
PhD student
Myogenesis; primary culture of muscle cells; mTOR signalling in skeletal muscles
Denis Falcetta
PhD student
Marco Kaiser
master student
bioinformatics, metaanalysis
Kathrin Chojnowska
PhD student
metabolism - mTOR signalling - Ca++ signalling
Maurizio Sury
master student



Lab Dr. Francesco Santini

Division of Radiological Physics, University Hospital Basel

Institute infrastructure: 1.5T and 3T human MRI scanners for in vivo imaging and spectroscopy, electronics laboratory, access to 31P coils for in vivo human spectroscopy and MR-compatible ergometer.

TeamPersonal expertise
Prof. Oliver Bieri
Methodological development, novel contrast mechanisms.
Dr. Francesco Santini
senior scientist
Methodological development, dynamic  MRI; MRI Safety; electronics design and development.
Dr. Xeni Deligianni
Methodological development, quantitative and dynamic MR imaging and spectroscopy; MR image and data analysis.
Dr. Monika Gloor
Methodological development, MR relaxometry and fat-water quantification; data postprocessing.
Tanja Haas




Lab Prof. Smita Saxena

University of Bern, Institute of Cell Biology

Institute infrastructure: Confocal Microscopy, Spinning Disk microscopy for live and Calcium imaging, muscle force measurement; cell culture; voluntary wheel running; rotarod,Stereotaxy, laser dissection microscopy

TeamPersonal expertise
Smita Saxena
Degeneration of motor neruons and neuromuscular junctions in ALS, muscle factors that influence axonal regeneration status, mTOR signalling in motor neurons
Grace Iyirhiaro
The ER-mitochondria axis in ALS



Lab Prof. Leonardo Scapozza

University of Geneva, Pharmaceutical Biochemistry

Institute infrastructure: Setup for measuring isometric force in sedated living mice or rats; Setup for measuring isometric and eccentric force in excised muscle; Setup for fluorescent imaging in living cells, mdx5Cv dystrophic mouse, mdx5Cv mice bearing conditional mutations for aromatase, estrogen receptors alpha and beta, cell culture facilities (P2 level), HTP plate readers, genomics platforms with capacity for RNA-sequencing and qPCR

TeamPersonal expertise
Prof. Leonardo ScapozzaBiophysics of interactions: ITC, SPR, Thermophoresis, Enzymology
Medicinal Chemistry: Cpds synthesis
Biochemistry: protein expression (mg scale), protein purification, target-based in vitro assay, protein characterization (SEC, SEC-MALS)
Dr. Olivier Dorchies
Senior Research Associate
Primary cultures of mouse skeletal muscle, in vivo force measurements, in vivo motor function (spontaneous locomotor activity, grid test, wheel running), influxes of radioactive calcium and sodium, fluorescent detection of ROS, roles of ROS and estrogen receptors in muscle dystrophy 
Dr. Hesham Ismail
Ex vivo force measurements, fluorescent imaging of intracellular pH, sodium fluxes, calcium fluxes, ROS, roles of ROS in muscle dystrophy
Elinam Gayi
PhD student
Management of multiple mutant mouse colonies, roles of estrogen receptors in muscle dystrophy
Dr. Amparo Garcia-Lopez
In vivo and in vitro study of RNA splicing, screening and characterization of RNA-binding molecules, study of neuromuscular diseases at the molecular and cell biology levels.
Ophélie Patthey-Vuadens
Histological evaluation of skeletal muscles



Lab Prof. Michael Sinnreich

University of Basel, Department Neurologie & Biomedizin

Institute infrastructure: Translational research on muscular dystrophies

TeamPersonal expertise
Michael Sinnreich

Neuromuscular diseases
Muscular Dystrophies

Dr. Lionel Tintignac
senior scientist
Myogenesis; primary culture of muscle cells; gene profiling
Marielle Brockhoff 
PhD student
Biochemistry, Molecular Biology, Cell Biology
Ruben Herrendorff
PhD student
Pharmaceutical Sciences, Biochemistry, Cell Biology
Jochen Kinter
experinece in NGS, drug screenings, aptamers
Tatiana Wiktorovic
viral vectors
Beat Erne
Histology, Histochemistry, Biochemistry
Adeline Stiefvater
Biochemistry, Cell Biology, Molecular Biology



Lab Profs. Susan Treves and Francesco Zorzato

University of Basel, Biomedicine

Institute infrastructure: excitation contraction, identification and characterization of novel proteins involved in calcium regulation in skeletal muscle and calcium homoestasis

TeamPersonal expertise
Susan Treves
Francesco Zorzato
force measurements and Ca++ imaging in single muscle fibers
Ruben Lopez
PhD student
single fibers dissection, SPARK analysis
Ori Rokach
PhD student
qPCR, electroporation
Marijana Sekulic
PhD student
superresolution microscopy (STORM), extraocular muscles
Alexis Ruiz
PhD student
Anne-Sylvie Monnet
Research Assistant



Lab Prof. Beat Trueb


University of Bern, Department of Clinical Research

Institute infrastructure: common

TeamPersonal expertise
Beat Trueb
common cloning techniques
common cell culture techniques
breeding and geno-typing of knock-out mice
whole-mount in situ hybridization
cell fusion assay
Dr.Lei Zhuang
Dr. Philippe Beauchamp



Lab Dr. Bernhard Wehrle-Haller

University of Geneva, School of medicine

Institute infrastructure: Microscopy, live-cell imaging, cell culture, fluorescent proteins

TeamPersonal expertise
Dr. Bernhard Wehrle-Haller
dynamic regulation of cell-matrix adhesions, live cell imaging, cell culture, FRAP, microscopy, live imaging

Patricia Vazquez
fluorescent tag-proteins, live imaging, FRAP, integrin signalling
Magda Ripamonti
PhD student
FRAP, integrin signalling



Lab Prof. Werner Z'Graggen

Inselspital Bern, Department of Neurology

Institute infrastructure: equipment for muscle and nerve excitability measurements, ENMG equipment, muscle MR imaging, histology, mitochondrial activity essays


TeamPersonal expertise
Prof. Hugh Bostock
PhD, researcher
Musle and nerve excitability measurements